Alzheimer's disease analytes

Returns a tibble containing curated metadata for directly measurable analytes relevant to Alzheimer's disease research. This includes amyloid beta peptides, total tau, phospho-tau isoforms, neurofilament light chain (NfL), GFAP, and alpha-synuclein.

Usage

analytes()

Value

A tibble with the following columns:

analyte_id

Unique identifier for the analyte. Based on ChEBI or UniProt, with suffixes for specificity.

analyte_name

Concise scientific label (e.g., "Aβ42", "p‐tau181").

analyte_full_name

Expanded form of the analyte name.

molecular_type

NCIT concept code corresponding to the molecular class, e.g. "peptide", "protein", based on NCIT vocabulary.

description

Brief description of the analyte's biological function or relevance to Alzheimer's disease.

Details

The table provides standardized identifiers, human-readable names, molecular types based on NCIT terminology, and concise descriptions of biological relevance. analyte_id values are drawn from external ontologies such as ChEBI or UniProt, optionally suffixed to reflect post-translational modifications (e.g. P10636-pT181) or structural fragments (e.g. P10636-MTBR243).

See also

assays(), biomarkers()

Examples

analytes()
#> # A tibble: 12 × 5
#>    analyte_id     analyte_name analyte_full_name      molecular_type description
#>    <chr>          <chr>        <chr>                  <chr>          <chr>      
#>  1 CHEBI:64647    Aβ42         Amyloid beta 1-42      C735           42-amino a…
#>  2 CHEBI:64646    Aβ40         Amyloid beta 1-40      C735           40-amino a…
#>  3 P10636-pT181   p‐tau181     Phosphorylated tau at… C1897          Tau protei…
#>  4 P10636-pT202   p‐tau202     Phosphorylated tau at… C1897          Emerging t…
#>  5 P10636-pT205   p‐tau205     Phosphorylated tau at… C1897          Tau protei…
#>  6 P10636-pT217   p‐tau217     Phosphorylated tau at… C1897          Highly spe…
#>  7 P10636-pT231   p‐tau231     Phosphorylated tau at… C1897          Potential …
#>  8 P10636-MTBR243 MTBR‐tau243  Microtubule-binding r… C20385         Fragment o…
#>  9 P10636         t‐tau        Total tau              C735           Full-lengt…
#> 10 P07196         NfL          Neurofilament light c… C735           Axonal dam…
#> 11 P14136         GFAP         Glial fibrillary acid… C735           Astrocytic…
#> 12 P37840         αSyn         Alpha-synuclein        C735           Presynapti…